We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.
Health

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

What is Kleine-Levin Syndrome?

Tricia Christensen
By
Updated: May 17, 2024
Views: 5,689
Share

Kleine-Levin Syndrome (KLS) is a mystifying neurological disorder most affecting young men and women in adolescence and lasting into young adulthood. KLS produces extended bouts of extreme sleepiness and impaired cognition that is paired with significant reduction in emotional sensitivity. These bouts can last for weeks to months, making it impossible for a person to participate in normal activities, and they can recur, with the condition lasting as long as ten years. With little successful treatment for Kleine-Levin Syndrome, a person may be robbed of their ability to be a full participant in life for years, until recovery occurs.

KLS has also been called Sleeping Beauty syndrome and of its symptoms, the most recognizable is hypersomnolence, or very long periods of sleep. A person with this disease may only wake to use the restroom or to eat something, and when awake, behavior is very different than normal. People in the awake state, when experiencing a bout of hypersomnolence, usually are apathetic or unfeeling, and the expression “spaced out” has been used to describe cognitive range.

During these bouts it isn’t possible to simply talk the person out of being sleepy or adopt a “bootstraps” mentality to make them get up. Apathy means emotion can’t be appealed to and the level of understanding may be poor in any case. Even with use of stimulants to wake the person up, the behavioral features may remain present and participating in normal activities could still be difficult or impossible.

In some people, the features of Kleine-Levin Syndrome go farther during the most active bouts of the condition. Some people become hypersexual and they may be less able to observe normal boundaries regarding sex during this time. There’s also higher incidence of overeating, which may correlate to higher weight levels if bouts last long or occur often.

The causes of Kleine-Levin Syndrome aren’t fully understood and some feel the condition is related to disorders like bipolar disorder. To this end, some doctors may treat KLS with mood stabilizers like lithium or carbamazepine. It’s not clear if these are fully successful, though they do prove useful for some people. What is most puzzling is that ultimately, people recover from this disease, usually when they are in their 20s, though some people might still have occasional, less severe episodes.

When KLS does resolve, this often means people must do a lot more to attempt to recover some of the things they’ve lost as a result of the disease. Many people with Kleine-Levin Syndrome have missed out on being able to complete important milestones like high school and college graduation. They may need support to make up for these things so they can pursue life fully. Psychological support is advised, as people with KLS may feel isolated or grieve some of the life they have lost while they suffered these episodes.

Share
WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Tricia Christensen
By Tricia Christensen
With a Literature degree from Sonoma State University and years of experience as a WiseGeek contributor, Tricia Christensen is based in Northern California and brings a wealth of knowledge and passion to her writing. Her wide-ranging interests include reading, writing, medicine, art, film, history, politics, ethics, and religion, all of which she incorporates into her informative articles. Tricia is currently working on her first novel.

Editors' Picks

Discussion Comments
By anon323367 — On Mar 05, 2013

As someone with KLS, I have not seen any published primary research suggesting it is similar to bipolar disorder. Due to the rarity, medical professionals -- even consultants -- frequently misdiagnose the condition, often believing it to be a psychiatric disorder such as bipolar or chronic fatigue syndrome. However, KLS is a distinct neurological disorder (it is thought to be a dysfunction of the hypothalamus - this regulates sleep, hunger and temperature).

Others with KLS, like me, do not find drugs useful during full blown episodes, stimulants may stop sleep, but still leave severe cognitive and behavior impairment and still need to be cared for to remain safe during this time.

This is a horrid condition to have, especially before it's diagnosed. If you mostly live by yourself it can be difficult to know what's happened since recollection of memory and time are affected.

By alex94 — On Sep 27, 2010

@stormyknight: I have heard about the KLS foundation. I think that they partnered with Stanford University Sleep Center to start a clinical research program on KLS.

They took clinical data and blood samples from 108 people that have been diagnosed with Kleine-Levin Syndrome. They even took samples from the patients’ parents to study the genetics of it. So far, they have found that 15% of U.S. patients with KLS were of Jewish heritage. That suggests a genetic founder effect with the Jewish population.

By StormyKnight — On Sep 27, 2010

There was a foundation established in 1999 called the Kleine-Levin Syndrome Foundation, Inc. to identify and support people affected by KLS. They are trying to raise awareness of KLS. As a matter of fact, they joined in with a FoxTV News affiliate to air a show about a 15 year old boy suffering from KLS. He was in a KLS hypersomnia episode and the family allowed the filming of it.

Tricia Christensen
Tricia Christensen
With a Literature degree from Sonoma State University and years of experience as a WiseGeek contributor, Tricia...
Learn more
Share
https://www.wisegeek.net/what-is-kleine-levin-syndrome.htm
Copy this link
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.