Dofetilide is a anti-arrhythmic drug used to treat heart rhythm problems that originate in the upper chamber of the heart. The upper chamber, or atrium, is responsible for controlling blood flow into the heart. Individuals with atrial flutter and atrial fibrillation are often prescribed dofetilide. Treating an irregular heart beat reduces the risk of developing blood clots, which in turn, reduces the risk of stroke and heart attack.
Careful monitoring by a physician is required during treatment with Dofetilide. It should not be taken by someone with kidney disease, or a history of Long QT syndrome. Additionally, many different over the counter and prescription medications can interact with this medication. It is important to make a list of every medication, vitamin, and supplement taken, and provide it to the healthcare provider before taking dofetilide.
The possibility of dofetilide negatively impacting heart and kidney function makes close monitoring important when starting the medication. Individuals are typically hospitalized during the first three days of taking this medication for easy monitoring. Regular heart and kidney function tests are necessary for as long as the individual remains on the medication. Blood pressure should be recorded daily.
Although dofetilide is used to treat heart arrhythmia, one potentially dangerous side effect is the development of a new, dangerous arrhythmia. This side effect is rare, and is the reason why close monitoring is necessary. Other potentially serious side effects are loss of appetite or thirst, fainting, a faster heart rate, chest pain, and severe dizziness.
Allergies to the medication are rare, but possible. Symptoms of allergies include swelling of the throat, face, or tongue. Itching, rash, and trouble breathing may also occur. Anyone who believes they are allergic to this medication should consult their physician immediately.
It is important that adequate levels of the drug remain in the body to maintain a regular heart rhythm. An illness that involves diarrhea, vomiting, or excessive sweating that lasts 24 hours, or is combined with the inability to take in adequate food or water, can interfere with levels of the medication in the blood. Contacting a doctor before taking the next scheduled dose minimizes the risk of serious side effects.
Dofetilide works by relaxing the overactive heart, helping it maintain a regular rhythm. The medication is typically taken in twice daily doses. It is important to note that while dofetilide controls heart arrhythmia, it does not cure the condition. It is normal to feel better while taking the medication, but it is important to continue taking it as prescribed.