Collagenase clostridium histolyticum is a medication prescribed for the treatment of Dupuytren's contracture. Patients with this medical condition have abnormal connective tissue in the hand, which gradually pulls one or multiple fingers into an awkward position. When this happens, it forms a thick cord of tissue. Collagenase clostridium histolyticum may only be used in patients who have a noticeable, or palpable cord of tissue. It contains proteins that can break down the cord's tissues, allowing the fingers to straighten.
This medication is only available as an injection to be administered by a doctor or nurse. He will use a needle to administer the medicine directly into the cord of tissue and then wrap the hand with a bandage. Patients must refrain from attempting to straighten the finger and limit mobility in the affected hand for as long as the doctor recommends. The hand should also be kept elevated.
On the day following the injection, patients should return for a follow-up visit. Depending on each individual patient's response to the drug, the doctor may attempt to break the cord and straighten the finger during this appointment. Patients may need to wear a finger splint for awhile and perform physical therapy exercises with the affected hand.
Some side effects may occur with the use of collagenase clostridium histolyticum for Dupuytren's contracture, which should be reported to the prescribing physician if they become severe. Patients may experience pain or tenderness at the injection site or at the underarm, swelling of the underarm, and warmth or redness in the skin. The injection site may display swelling, bruising, or bleeding. Patients may also notice itching or breaks in the skin.
More serious side effects can also occur, which require immediate medical care. Nerve damage is possible, which may present with increased pain in the treated area, numbness, or tingling. Some patients may suffer from damage to the tendons or ligaments. This may be indicated by difficulty bending the affected finger toward the wrist after the doctor has approved increased mobility in that hand. Some patients may also have an allergic reaction, which can be indicated by facial swelling, tightness in the chest, and problems breathing.
Before using collagenase clostridium histolyticum, patients must disclose their other medical conditions, medications, and supplements. It may be contraindicated for use by those with a bleeding problem or women who are pregnant or breastfeeding. Collagenase clostridium histolyticum may interact with blood thinning medications, excluding low-dose aspirin.