We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.
Health

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

What Factors Affect a Sufficient Cefixime Dose?

By Maggie J. Hall
Updated: May 17, 2024
Views: 6,824
Share

Patient age and kidney health generally factor into determining a sufficient cefixime dose. Sufficient doses of the antibiotic must effectively treat infections while not placing undue stress on bodily functions. Taking certain medications for diabetes may affect absorption time but does not require dosage adjustments. Physicians may monitor patients taking cefixime with an anticoagulant and the seizure medication carbamazepine.

Cefixime is a semi-synthetic medication that belongs to the category of antibiotics commonly referred to as cephalosporins. It eliminates susceptible bacteria by interfering with the ability to develop protective cellular walls, making the organism vulnerable to attack. Cefixime has broad-spectrum capabilities, meaning the medication effectively kills a long list of gram-positive and gram-negative bacteria. Some of the susceptible strains of bacteria include several types of Streptococcus, Escherichia coli, and Salmonella. Cefixime is also used to treat gonorrhea.

Health care providers usually prescribe cefixime for ear infections, tonsillitis, respiratory infections, and urinary tract infections. It is available in both a liquid suspension and as a tablet. Patients may take the medication with or without food as eating prior to taking cefixime delays absorption time by less than one hour.

The typical adult cefixime dose is 400 milligrams, taken once daily. Physicians generally determine a pediatric cefixime dose based on the weight of the child. Children older than six months usually receive 8 milligrams per kilogram of body weight while children over the age of 12 or who weigh more than 110 pounds (50 kilograms), receive a normal adult dose. Adult and pediatric patients might also divide the daily amount into two doses, taken once every 12 hours.

The kidneys eliminate most of cefixime from the body. Patients with kidney disease cannot eliminate the medication properly, causing increased blood levels of cefixime. Renal impairment may require a reduction of the cefixime dose by 50% to 75%. Dialysis does not eliminate the medication from the blood. Combining cefixime with aminoglycoside antibiotics may eliminate a wider range of microbes but increases kidney stress during elimination.

Frequently reported side effects of cefixime include diarrhea and abdominal discomfort, and some patients experience headaches and dizziness. Patients with an allergy to penicillin may also develop cross-sensitivity reactions to cefixime. Taking cefixime increases the likelihood of overgrowth in yeast colonies, which can cause vaginal discomfort. Pharmaceutical companies generally do not recommended cefixime for patients with gastrointestinal disorders or Clostridium infections as risks include exacerbation of gastric symptoms.

Combining carbamazepine with cefixime increases the blood levels of the carbamazepine, and cefixime increases the anticoagulant action of warfarin and similar medications. Patients who use probenecid while taking the antibiotic exhibit increased levels of cefixime. The diabetic medication exenatide increases the absorption time of cefixime, and patients should take these drugs at least one hour apart.

Share
WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Editors' Picks

Discussion Comments
By ddljohn — On Mar 28, 2014

The tablets are 400mg but the suspensions come in different doses like 100mg and 200mg. The suspensions are usually used in hospital settings and for children.

I agree that the directions of the doctor should be followed carefully when using cefixime. I was also on a 400mg dose per day. My doctor had me take it for several days but when my symptoms did not lessen in that time frame, he extended the treatment for several more days which did the trick.

By stoneMason — On Mar 27, 2014

@candyquilt-- I'm not sure. When I took cefixime, I took 400mg/day for seven days. I think that 400mg is the normal daily dosage but the treatment may last longer or shorter depending on the infection.

Cefixime is one of the antibiotics used for gonorrhea and as far as I know, a single dose of antibiotics is sometimes used for sexually transmitted diseases caused by bacteria. But don't try to treat yourself, make sure that you see a qualified doctor and have him or her determine the needed dose and treatment period. Otherwise the infection will not go away.

By candyquilt — On Mar 27, 2014

There is also a single dose cefixime right? What is the single dose used for?

Share
https://www.wisegeek.net/what-factors-affect-a-sufficient-cefixime-dose.htm
Copy this link
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.