Nabumetone tablets are used to treat pain and swelling in clinical conditions such as osteoarthritis and rheumatoid arthritis. They are available under different trade names in different countries, according to manufacturer. Two different strengths, 500 mg and 750 mg, may be available, depending on the country. The tablets require a doctor's prescription in most countries, but may be available over the counter in some.
The mechanism of action of nabumetone tablets is via prostaglandins. These are substances in the body that cause pain and swelling in response to trauma or injury. By blocking cyclooxygenase (COX), which is necessary for the production of prostaglandins, nabumetone tablets may stop the pain and swelling. They belong to the class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). Other examples of these include aspirin and ibuprofen.
The number of nabumetone tablets used will depend on the condition being treated and the strength of the tablets used. They are usually given once or twice daily depending on tolerance and response to the medication. The dosage and dosage schedule prescribed by the doctor should not be exceeded, as this may increase the risk of toxicity and possible adverse effects. Nabumetone's adverse effects include gastrointestinal problems that may be lessened by taking the tablets with or after food or a glass of milk. Should any untoward effects occur during treatment, medical advice should be obtained.
Interactions may occur between nabumetone tablets and other medications. Any concurrent drugs should be discussed with the prescribing doctor before starting treatment. They should also not be taken in combination with drugs that may increase bleeding risk, such as other NSAIDs and some antidepressants. Some combination cold and flu medications may contain NSAIDs.
Hypersensitivity or allergic reactions to NSAIDs have been reported, and it is vital that the doctor be informed of any such history. This applies to a reaction to any NSAID, not just a previous reaction to nabumetone. The drug may be contraindicated or require dosage adjustments in certain population groups or clinical conditions, such as the elderly and those with renal dysfunction.
Patients with a history of gastric or peptic ulcer or bleeding should not take nabumetone tablets. Pregnancy, desired pregnancy and lactation should be discussed with the prescribing doctor. Nabumetone tablets may be used short-term but often are used chronically, over a long period of time. The lowest effective dose will be prescribed for chronic use.
