We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.
Health

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

What Are the Different Types of Chemotherapy Chemicals?

By M.R. Anglin
Updated: May 17, 2024
Views: 7,359
References
Share

Some of the different types of chemotherapy chemicals are alkylating agents, antimetabolites, and plant alkaloids. Doctors may also use anthracyclines to treat various forms of cancer. All chemotherapy chemicals have one goal: to kill off cancer cells. To do this, most of these drugs target a cell’s ability to divide — a process called mitosis, which cancer cells undergo uncontrollably. The more rapidly a cell divides, the more likely a chemotherapy drug will target it, which explains why normally rapidly dividing cells, like those found in hair follicles, may also be affected.

A cell undergoing mitosis must first replicate its deoxyribonucleic acid (DNA) and then separate into two identical daughter cells. Many chemotherapy chemicals work to alter or damage a cell’s DNA because if it is altered or damaged enough, and the cell will undergo programmed cellular death, a process called apoptosis. Each chemotherapy chemical may seek to accomplish this goal in a different way. For example, anthracyclines work by intercalating, or inserting themselves, within the DNA double helix’s nucleotides and also by causing free-radical damage. This interrupts the DNA’s ability to replicate itself and can cause mutations within the cell.

An alkylating agent, another form of chemotherapy chemicals, works to disrupt cell division by bonding with DNA and altering it. It does this by using electronegativity, a term used to describe a cell’s desire to draw electrons. When the DNA bonds with the alkylating agent, the agent disrupts the cell’s ability to divide properly, a result which could lead to apoptosis. Since this chemotherapy chemical can work at all points of a cell’s life cycle, it is called a non cell cycle specific drug. The drug can be used to treat a variety of different cancers, but because it damages DNA, it may also lead to the development of certain types of leukemia.

Plant alkaloids are chemotherapy chemicals that are derived from plant sources. Two types of plant alkaloids are antimicrotubule agents and topoisomerase inhibitors. Antimicrotubule agents work to prevent cell division by inhibiting the function of microtubules, small, spindle like structures that help pull the two daughter cells apart. Topoisomerase inhibitors disrupt the DNA’s ability to repair itself. These drugs are cell cycle specific and only affect cells that are in a certain phase in its life cycle.

Another of the chemotherapy chemicals, the antimetabolites, prevents the cell from metabolizing certain chemicals. There are different types of antimetabolites, and each disrupts the metabolizing of specific substances. For example, folate antagonists, disrupts the ability of the cell to incorporate folate, a substance necessary for DNA synthesis. Similarly, purine antagonists disrupt the cell’s ability to incorporate purine, a building block of DNA. Without the proper substances in the cell, the cell is not able to divide.

Share
WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Link to Sources

Editors' Picks

Discussion Comments
Share
https://www.wisegeek.net/what-are-the-different-types-of-chemotherapy-chemicals.htm
Copy this link
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.