Amitriptyline is a tricyclic antidepressant medication that a doctor may prescribe to treat depression. This drug has the potential for serious interactions and side effects, particularly when it is used in certain patients. Amitriptyline interactions may occur with other drugs and with certain medical conditions. Patients should follow all dosage instructions carefully to lessen the risk of side effects, overdose, and other amitriptyline interactions.
Certain medicines should not be used at the same time as this antidepressant, such as tranquilizers, sleeping pills, and diet pills. Serious amitriptyline interactions may occur if it is used within 14 days of using a monoamine oxidase (MAO) inhibitor such as selegiline or phenelzine. Patients should disclose all other medications and supplements they are taking, especially antihistamines, selective serotonin reuptake inhibitors (SSRIs), and other antidepressants. Amitriptyline interactions may also occur if the drug is used along with medications to treat Parkinson's disease, seizures, and urinary problems, as well as irregular heartbeats, irritable bowel disease, and any mental illnesses. In addition, the patient may need an adjusted dose of amitriptyline if he has used fluoxetine in the previous five weeks.
Patients with certain medical conditions may be unable to use this drug, in order to avoid adverse interactions. Women who are pregnant should discuss potential risks with their doctors, while those who are breastfeeding should never use this drug. Patients should disclose all their other medical conditions, including whether they have heart disease, an overactive thyroid, or diabetes, because amitriptyline may interfere with a diabetic's blood sugar levels. A recent heart attack or a history of heart attacks, seizures, or strokes may prevent a person from taking this drug. Amitriptyline interactions may also occur in patients who have bipolar disorder, schizophrenia, and urinary problems.
Younger people should be aware that antidepressants like amitriptyline have been associated with an increase in suicidal thoughts and actions. They should inform their doctor immediately if they experience worsening depression, panic attacks, or aggressive and impulsive behavior. Parents and caregivers should monitor patients who are 24 years old or younger for signs of this reaction.
All dosage instructions should be followed carefully to avoid a possible overdose. Signs of an overdose may include hallucinations, loss of consciousness, and an irregular heartbeat. Patients may also exhibit confusion, agitation, and difficulty concentrating. An overdose of amitriptyline requires emergency medical care.
Additional special precautions should be followed to lessen the risk of amitriptyline interactions. For example, patients should avoid consuming alcohol, because this may cause excessive drowsiness. If surgery is planned, including dental work, the surgeon should be informed that the patient is using this drug. Elderly patients should be aware that they may be at a higher risk of side effects, and that the drug may not work as effectively for them.
