We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.
Health

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

What are Inotropes?

By Kevin Gill
Updated: May 17, 2024
Views: 18,530
Share

Inotropes are substances used to alter the energy of muscle contractions. These substances can be negatively inotropic or positively inotropic. Negatively inotropic agents decrease the energy of muscle contractions, and positively inotropic agents increase the energy of muscle contractions.

The most common association of inotropes is with contractions of the heart muscle. More precisely, inotropic agents typically are drugs that are used to affect the strength of the heart muscle contractions. These muscular contractions can be increased or decreased as necessary by using inotropic agents.

Natural conditions resulting from inotropic activity also exist. Increased inotropic activity can result from an enlarged heart muscle in a condition called ventricular hypertrophy. Decreased inotropic activity can be caused by myocardial infarction or dead heart muscle tissue, which is more commonly known as a heart attack.

Inotropes, whether they are positive or negative, are used to help manage cardiac conditions. Most inotropes work based on the amount of calcium in the cytoplasm of the muscle cell. This level is increased by positive inotropes and decreased by negative inotropes. Not all drugs work based on the release of calcium, and even among the ones that do, the mechanism of release can vary.

Negative inotropic agents are used to decrease myocardial contractility. This approach is used to relieve a strained or overworked heart. Care is exercised, because this treatment can lead to or exacerbate heart failure. Negative inotropic agents include certain beta blockers that have been proven to reduce mortality and morbidity in congestive heart failure. Negative inotropes include beta blockers, calcium channel blockers, class IA antiarrhythmics and class IC antiarrhythmics.

Conversely, to increase myocardial contractility, one would use a positive inotropic agent. This approach is used to treat several different heart conditions. Cardiomyopathy, decompensated congestive heart failure, myocardial infarction, cardiogenic shock and septic shock are the ailments most typically treated by positive inotropes.

Positive inotropic agents are many and varied. This group includes berberine, bipyridine derivatives, calcium, calcium sensitisers and catecholamines. The group also includes eicosanoids, phosphodiesterase inhibitors, glucagon and cardiac glycosides such as digoxin. Digoxin, or digitalis, is an extract from the foxglove plant.

Positive and negative inotropes can affect any types of muscles. They have shown the greatest usefulness in treating conditions of the heart muscle. The extreme importance of safe heart function means that inotropes likely will continue to have the most impact in the treatment of cardiac conditions.

Share
WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Editors' Picks

Discussion Comments
Share
https://www.wisegeek.net/what-are-inotropes.htm
Copy this link
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.