Lamotrigine for bipolar is considered effective for controlling depression linked to the disorder. Doctors treating this condition commonly prescribe lithium and lamotrigine for bipolar to prevent a relapse of depressive states. Lithium typically controls the mania, and the two drugs might work together to control cycling from one state to the other. In one research study, two-thirds of patients using lamotrigine for bipolar conditions gained relief from manic episodes.
This anticonvulsant drug has been used for years to treat seizures in epilepsy patients. In 1990, doctors began using lamotrigine for bipolar patients who did not respond well to other drugs approved for the disorder. Lithium represents the standard medication used to treat the mania associated with bipolar conditions. One other drug, olanzapine, is also effective, but typically causes weight gain.
Researchers believe lamotrigine for bipolar inhibits the release of calcium and sodium in certain neurons, which might delay the onset of acute mania when used with lithium. It generally reduces the mood cycling common with this disorder. Lamotrigine is considered stronger than other antidepressants used for the disorder, with fewer side effects.
These side effects are usually more pronounced when the drug dosage is increased. They may resolve in a few days for some patients. Typically, it might take a month or more to see results from using this medication.
Most side effects are mild, but a risk exists of developing a serious and potential fatal rash. The risk is greater when other drugs are used with lamotrigine or if the patient uses a high dose. Young people and the elderly are more prone to develop a rash, which might range from slight redness to lesions similar to poison oak rashes. One in 10 patients suffers some form of rash while using the medication.
Other side effects include dizziness, sleepiness, or an unstable gait. Some patients experience vision problems described as double vision or blurred vision. Vomiting, nausea, and diarrhea represent other common side effects of using lamotrigine for bipolar disorder. Since the drug’s use for mood disorders began, little information is available on long-term side effects.
In addition to treating mood disorders, lamotrigine might be effective to treat post-traumatic stress disorder, borderline personality disorder, and severe depression. It might also control seizures in patients with epilepsy. It is not recommended for most pregnant women because animal studies show lamotrigine can affect the fetus.
