The best way to heal a blister is to prevent further friction or damage, and just let the blister heal on its own. The blister itself acts as a natural bandage and helps to prevent infection; popping a blister can potentially introduce bacteria into the skin. Of course, this method may not always be possible with larger blisters, depending on where they are. In this case, to heal a blister it is best to sterilize a needle using rubbing alcohol, then gently pop the blister and allow the fluid to drain, and then treat the blister as you would any other injury to the skin.
Once the blister has been popped and the clear fluid has drained, leave the remaining skin over the blister if it appears clean; apply antibiotic ointment and an adhesive bandage. When trying to heal a blister like this, it is important to keep the area dry and clean, so change the bandage regularly and gently wash the area before applying more antibiotic ointment. It is also important to watch for signs of infections, which can include pus forming around the area, redness or red streaks surrounding the blister, a feeling that the blister is hot to the touch, or the presence of a fever in the body. Symptoms such as these might require antibiotics, particularly the presence of red streaks or a fever, so it will be necessary to visit a doctor.
Using this process to heal a blister will typically help the blister to heal within a few days. Be sure to protect the area from further damage by wearing different shoes, for example, if the blister was caused by friction. Keep in mind that if a blister is small, however, it may not be necessary to pop it in order to heal a blister. In this case, simply keeping the area clean and protected from further damage by wearing an adhesive circular blister pad around the area can be enough to encourage healing. Some people also apply aloe vera gel to the blister, to speed healing and prevent itching.
Blisters that seem to be filled with blood or anything other than clear fluid may need to be treated by a doctor. Again, it is important to note any symptoms that could indicate infection, and make note if the blister does not seem to be improving. Be sure to wear properly fitting shoes every day to prevent blisters on the feet, and protect the hands by wearing gloves if blisters are frequently occurring at work.